We then analyze plasma from patients with septic shock and find that increasing levels of IL-6 and bla TEM are associated with mortality, while decreasing IL-6 levels are associated with recovery. We use our method to characterize bronchoalveolar lavage fluid from patients with asthma, and find elevated GN bacteria and IL-6 levels compared to healthy subjects. Our digital assay measures IL-6 and TNF- α proteins, gram-negative (GN) and gram-positive (GP) bacterial DNA, and the antibiotic-resistance gene bla TEM with femtomolar sensitivity. Here, we demonstrate sensitive and rapid quantification of bacterial load and cytokines from human biological samples to generate actionable hypotheses. ![]() Quantification of pathogen and host biomarkers is essential for the diagnosis, monitoring, and treatment of infectious diseases.
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